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Clozapine and “high-dose” olanzapine in refractory early-onset schizophrenia: A 12-week randomized and double-blind comparison.

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Life events and difficulties experienced one year prior to onset (cases) or interview (controls) were assessed with the Life Events and Difficulties Schedule.

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Conclusion: Internalized stigma was associated with socioaffective constructs among HRP individuals, and reducing stigma might ameliorate anxiety and depression.

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Also excluded were those with mental retardation, an organic mental disorder, previous brief reactive psychosis, those who had received long-acting intramuscular neuroleptic medication within 4 weeks of the first day of double-blind treatment (unless blood level was below therapeutic level), and those judged by the investigator to be at imminent risk of suicide or homicide.

Comparison of intramuscular olanzapine, orally disintegrating olanzapine tablets, oral risperidone solution, and intramuscular haloperidol in the management of acute agitation in an acute care psychiatric ward in Taiwan.

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Previous studies have not looked at the prevalence of autoantibodies to N-Methyl-D-Aspartate receptor (NMDA-R), Voltage Gated Potassium Channel (VGKC) and Glutamate Decarboxylase (GAD) in the initial acute phase of FEP compared to healthy comparison subjects.

Two auditory oddball paradigms were administered at the end of COGS-2 testing day under passive and active conditions to in order to assess mismatch negativity and P300 measures (P3a and P3b) via a custom 2-channel EEG recording system.

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We present the mean change scores using an ANCOVA model and rate of change (per week) using a linear mixed-effects model.

Methods: PRS subjects were recruited using 2 step methods, screened using Prodromal Questionnaire-Brief version (PQ-B) and interviewed with Structured Interview for Prodromal symptoms (SIPS).

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Paliperidone extended-release: a review of efficacy and tolerability in schizophrenia, schizoaffective disorder and bipolar mania.

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Methods: 18 individuals with severe mental illness were randomized to two weeks of either active or placebo working memory training.

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Examine methylation profiles in children diagnosed with FASD compared to children with other psychiatric disorders to evaluate whether there are distinctive patterns of methylation associated with in utero exposure to alcohol.

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Conclusion: DR of antipsychotics during early stages of remitted FEP significantly improved 7-years outcome in terms of recovery and functional remission compared to maintenance treatment.

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Wallenberg, is experiencing postural hypotension as a side effect of his low-potency antipsychotic medication chlorpromazine (Thorazine).

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Work from studies of post-mortem schizophrenia tissue shows increased SNARE protein-protein interactions in schizophrenia (2), supporting findings from the blind-drunk mouse, a mutant with increased syntaxin-SNAP-25 interaction and phenotypic features of schizophrenia (3).

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Patients with risk factors for diabetes (obesity, family history of diabetes) should undergo fasting blood sugar testing at the beginning of atypical antipsychotic treatment and periodically during treatment.

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Another study compared quetiapine to placebo in patients already determined to be delirious who had an as-needed haloperidol order and found that the patients who received quetiapine experienced a faster resolution of delirium, less delirium, less agitation, and more somnolence.

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Using MNE-python, phase slope index (PSI) was computed relative to superior temporal gyrus (STG) for AVH onset and offset in the theta and alpha bands.

Furthermore, in the analysis using the last observation carried forward, greater improvements in depressive and anxiety symptoms in the olanzapine group were found, as determined with the Montgomery-Åsberg Depression Rating Scale and Hamilton anxiety scale, respectively.

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Methods: The Recovery After an Initial Schizophrenia Episode (RAISE) project is an NIMH-funded 34 site randomized controlled trial evaluating the benefits of participation in a multicomponent pharmacological and psychosocial intervention, NAVIGATE, on clinical and functional outcomes after a first psychotic episode.

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It is indicated for acute and maintenance treatment of schizophrenia.

Luccille is prescribed the antipsychotic olanzapine (Zyprexia) 20 mg total daily, to be given in two equally divided doses every 12 hours.

Methods: 59 healthy persons (H), 41 SZ, and 55 BDP completed blocked pro- and anti-saccade tasks while electroencephalography (EEG) data was gathered on a 64 channel NeuroScan system.

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Metabolism and Elimination: Ziprasidone is extensively metabolized after oral administration with only a small amount excreted in the urine (greater then 1%) or feces (greater then 4%) as unchanged drug.

We describe the development of The Calgary First Episode Psychosis Team Scale (CFEPS) and compare the components and measurement scales with three other scales, two used in North America and one in the United Kingdom.

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Additionally both the Cochrane Library (2011, Issue 1) and Centre for Reviews and Dissemination databases (DARE, NHS EED and HTA) were searched for systematic reviews and cost effectiveness studies.

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Views about the long-term efficacy of antipsychotics are often based on the results from short-term (0-3 years) evaluations.

Access to medical care among persons with psychotic and major affective disorders.

Neurocognition (NC)-composite score was similarly derived from the MATRICS Consensus Cognitive Battery, sans the MSCEIT.

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Risperidone tends to cause weight gain, but less so than either clozapine or olanzapine (see weight gain below).

Gill EE. The immunology of host defence peptides: beyond antimicrobial activity.

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The investigators seek to examine specimens gathered by the Autism Genetic Resource Exchange (AGRE) from individuals with autism spectrum disorders (ASD) and their family members (when available), and American Type Culture Collection, other biomaterial repositories, and NIH studies and undergo the.

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We focused the proteomc analysis in discovering biomarkers candidates with predictive power to a successful medication response.

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While some clinicians argue for their superior efficacy compared to oral antipsychotics based on enhanced compliance management, others hold reduced patient autonomy and limitations in the possibilities for dose adjustment against them.

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